%0 Journal Article
%T Comparative evaluation of atenolol and clonidine premedication on cardiovascular response to nasal speculum insertion during trans-sphenoid surgery for resection of pituitary adenoma: A prospective, randomised, double-blind, controlled study
%A Gupta Devendra
%A Srivastava Shashi
%A Dubey Rajeev
%A Prakash Prabhakar
%J Indian Journal of Anaesthesia
%D 2011
%I Medknow Publications
%X Severe cardiovascular responses in the form of tachycardia and hypertension following nasal speculum insertion occur during sublabial rhinoseptal trans-sphenoid approach for resection of small pituitary tumours. We compare the effects of preoperative administration of clonidine (¦Á-2 agonist) and atenolol (¦Á-blocker) over haemodynamic response, caused by speculum insertion during trans-sphenoid pituitary resection. We enrolled 66 patients in age range 18-65 years, of ASA I-II, and of either sex undergoing elective sublabial rhinoseptal trans-sphenoidal hypophysectomy. Group I (control) received placebo, group II (clonidine) received tablet clonidine 5 ¦Ìg/kg, and group III (atenolol) received tablet atenolol 0.5 mg/kg. The heart rate increased on speculum insertion and 5 and 10 minutes following speculum insertion as compared to the pre-speculum values in the control group, while no change in the heart rate was observed in other groups (P<0.05). There was a rise in the mean arterial pressure during and 5, 10, and 15 minutes after nasal speculum insertion in the control group, whereas it was not seen in other groups (P<0.05). We therefore suggest that oral clonidine and oral atenolol (given 2 hours prior to surgery) is an equally effective and safe method of attenuating haemodynamic response caused by nasal speculum insertion during trans-sphenoid pituitary resection.
%K Anaesthetic techniques
%K atenolol
%K clonidine
%K drug
%K general
%K procedure
%K trans-sphenoid pituitary resection
%U http://www.ijaweb.org/article.asp?issn=0019-5049;year=2011;volume=55;issue=2;spage=135;epage=140;aulast=Gupta