%0 Journal Article
%T Evidence of association between type 1 diabetes and exposure to enterovirus in Cuban children and adolescents
%A Luis Sarmiento
%A Ileana Cubas-Due£¿as
%A Eduardo Cabrera-Rode
%J MEDICC Review
%D 2013
%I Medical Education Cooperation with Cuba (MEDICC)
%X A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic ¦Â cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective preventive strategies.
%K Type 1 diabetes
%K juvenile diabetes
%K insulindependent diabetes
%K autoimmunity
%K autoantibodies
%K enteroviruses
%K hygiene hypothesis
%K Cuba
%U http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1555-79602013000100007