%0 Journal Article
%T Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions
%A Zheltonozhskaya T.B.
%A Partsevskaya S.V.
%A Klymchuk D.O.
%A Gorchev V.F.
%J Proceedings of the International Conference Nanomaterials : Applications and Properties
%D 2013
%I Sumy State University
%X Encapsulaton of poorly soluble crystallizing drug prednisolone (PS) in micellar solutions of PAAm-b-PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide (MnPEO=6 kDa, MnPAAm=116 kDa) was studied by dynamic light scattering and transmission electron microscopy. The equilibrium mechanism of the encapsulation process and the effect of specific aggregation of PS-loaded micelles by their ¡°coronas¡± that promoted the drug crystallization were established. The question about the presence of TBC micelles inside crystalline space was discussed.
%K Nanoparticles synthesis
%K Nanoparticles study
%K Controlled properties
%K Producing processes
%K Complex structure
%U http://nap.sumdu.edu.ua/index.php/nap/nap2013/paper/view/1227