%0 Journal Article
%T DIAGNOSTIC VALUE OF SIMULTANEOUS MEASUREMENT OF PROCALCITONIN, INTERLEUKIN-6 AND HS CRP IN PREDICTION OF EARLY-ONSET NEONATAL SEPSIS
%A alireza abdollahi
%A saeed shoar
%A fatemeh nayyeri
%A mamak shariat
%J Mediterranean Journal of Hematology and Infectious Diseases
%D 2012
%I 
%R 10.4084/mjhid.2012.
%X Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations .We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive- C reactive protein in prediction of early neonatal sepsis. We performed a follow- up study on 95 neonates who were below 12 hours (h) of age, had clinical signs of sepsis or maternal risk factors for sepsis. Neonates were assigned to 4 groups including ˇ°proven early-onset sepsisˇ±, ˇ°clinical early-onset sepsisˇ±, ˇ°negative infectious statusˇ±, and ˇ°uncertain infectious statusˇ±. Blood samples were obtained within the first 12 h of birth repeated between 24 hours and 36 hours of age for determination of serum levels of PCT, IL-6, high sensitivie- C Reactive Protein (hs-CRP), and white blood cell (WBC) count. On admission, neonates with sepsis had a higher WBC count, IL-6, PCT, and hs-CRP levels compared with those neonates without sepsis. This remained significant even after 12-24 hours of admission. Also, patients with clinical evidences of sepsis had a higher serum level of PCT and IL-6 within 12-24 hours after admission compared to the patients with uncertain sepsis. In final The combination of IL-6, hs-CRP, and PCT seems to be predictive in diagnosis of early onset neonatal sepsis.
%K Procalcitonin
%K interleukin-6
%K high sensitive- CRP
%K early neonatal sepsis
%U http://www.mjhid.org/article/view/10112