%0 Journal Article
%T Genetyka  uszczycy ¨C od bada¨½ serologicznych antygen¨®w zgodno ci tkankowej do bada¨½ asocjacyjnych ca ego genomu
%A Aneta Szczerkowska-Dobosz
%A Krzysztof R£¿ba£¿a
%J Przegl£¿d Dermatologiczny
%D 2011
%I Termedia Publishing House
%X Psoriasis is a complex disease with multifactorial mode of inheritance,whichmeans that its clinicalmanifestations depend uponmultiple genesinteracting with environmental agents. The major genetic factor responsiblefor 35-50% susceptibility for early psoriasis in the Caucasian population,HLA-Cw*06, is located within the major histocompatibility complex(MHC) on the sixth chromosome. Whole genome associationstudies, the newest research trend, revealed three genetic, non-MHCrelated pathways connected with psoriasis susceptibility: Th17, Th2 andNF-¦ÊB-dependent. These genes are responsible for inflammation, epidermalproliferation and epidermal barrier function in psoriasis.
%K EDC
%K GWAS
%K psoriasis
%K allele HLA-Cw*06
%K MHC
%U http://www.termedia.pl/Prace-specjalne-Genetyka-luszczycy-od-badan-serologicznych-antygenow-zgodnosci-tkankowej-r-ndo-badan-asocjacyjnych-calego-genomu,56,17698,1,0.html