%0 Journal Article
%T Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images
%A Ching-yee Wong
%A James Gannon
%A Jeffrey Bong
%A Christiana O Wong
%A Gopal B Saha
%J BMC Medical Physics
%D 2007
%I BioMed Central
%R 10.1186/1471-2385-7-5
%X 38 patients with histologically proven unilateral TLE due to pure hippocampal sclerosis, referred for pre-surgical PET evaluation of intractable seizure over a 5-year period, were included. The F-18 FDG images were oriented along temporal long axis and then transformed into ZPET images on a voxel by voxel basis. Multiple regions of interests (21 in total) were placed on cortical, subcortical and cerebellar structures on twenty-eight out of 38 patients with totally seizure-free (class I) outcome. Paired t-tests with Bonferroni correction were used to determine the location of the most asymmetric regions as variables for subsequent discriminant analysis of the entire group of the patients.The computer program identified the anterior half of the temporal lobe (p < 0.0005) and thalami (p = 0.021) as the most asymmetric regions in TLE patients with Class I outcome. Discriminant analysis using z-scores from a total of 8 ROIs (in 4 pairs) on these structures correctly lateralized thirty-seven out of 38 (97%) patients (sensitivity = 94%; specificity = 100%). The only false localization came from a patient with equivocal z-scores on the temporal lobes and this patient turned out to have poor outcome.The computer-assisted lateralization of TLE using ZPET provides an accurate, fast and objective way of seizure evaluation.The interictal state of temporal lobe epilepsy (TLE) is characterized by decreased uptake due to hypometabolism on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images. Spanaki et al. suggested that seizures might have a reversible effect on brain areas connected with, but remote from, the epileptogenic cortex [1]. Vinton et al found patients with medically refractory temporal lobe epilepsy to have a better surgical outcome when a greater proportion of the hypometabolic volume was resected [2]. Choi et al noticed that extratemporal cortical hypometabolism outside the seizure focus, in particular hypometabolism in the contralateral cerebral c
%U http://www.biomedcentral.com/1471-2385/7/5