%0 Journal Article
%T Planar Tc99m ¨C sestamibi scintimammography should be considered cautiously in the axillary evaluation of breast cancer protocols: Results of an international multicenter trial
%A Teresa Massardo
%A Omar Alonso
%A Augusto Llamas-Ollier
%A Levin Kabasakal
%A Uma Ravishankar
%A Rossana Morales
%A Luc¨ªa Delgado
%A Ajit K Padhy
%J BMC Medical Physics
%D 2005
%I BioMed Central
%R 10.1186/1471-2385-5-4
%X One hundred and forty-nine female patients were included prospectively from different regions. Their mean age was 55.1 ¡À 11.9 years. Histological report was obtained from 2.987 excised lymph nodes from 150 axillas. An early planar chest image was obtained at 10 min in all patients and a delayed one in 95 patients, all images performed with 740¨C925 MBq dose of Tc99m sestamibi. Blind lecture of all axillary regions was interpreted by 2 independent observers considering any well defined focal area of increased uptake as an involved axilla. Diagnostic values, 95% confidence intervals [CI] and also likelihood ratios (LR) were calculated.Node histology demonstrated tumor involvement in 546 out of 2987 lymph nodes. Sestamibi was positive in 30 axillas (25 true-positive) and negative in 120 (only 55 true-negative). The sensitivity corresponded to 27.8% [CI = 18.9¨C38.2] and specificity to 91.7% [81.6¨C97.2]. The positive and negative LR were 3.33 and 0.79, respectively. There was no difference between early and delayed images. Sensitivity was higher in patients with palpable lesions.This work confirmed that non tomographic Tc99m sestamibi scintimammography had a very low detection rate for axillary lymph node involvement and it should not be applied for clinical assessment of breast cancer.Lymph node status is the most important prognostic indicator in breast cancer in recently diagnosed primary lesion. The evidence of metastatic involvement in the axilla requires the indication of adjuvant therapy posterior to surgical tumor resection. There is not an accurate anatomical test for this purpose and clinical examination has inappropriate diagnostic values. Routine lymph node dissection is the only accepted method for therapeutic decisions but it is invasive and produces significant associated morbidity such as lymphedema and, eventually, infections. On the other hand, an important proportion of breast cancer patients are node-negative. Ultrasonography has also been reported as
%U http://www.biomedcentral.com/1471-2385/5/4