%0 Journal Article
%T Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? - A case report with review of literature
%A Goyal Manu
%A Mohammad Noorjahan
%A Palanki Satya
%A Vaniawala Salil
%J Indian Journal of Medical and Paediatric Oncology
%D 2010
%I Medknow Publications
%X Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date.
%K Flow cytometry
%K fluorescent in-situ hybridization
%K free light chains
%K primary plasma cell leukemia
%K transplant
%U http://www.ijmpo.org/article.asp?issn=0971-5851;year=2010;volume=31;issue=3;spage=142;epage=146;aulast=Goyal