%0 Journal Article
%T Change in quality of life after medical and surgical treatment of gravesˇä ophthalmopathy
%A Kashkouli Mohsen
%A Heidari Iraj
%A Pakdel Farzad
%A Jam Sara
%J Middle East African Journal of Ophthalmology
%D 2011
%I Medknow Publications
%X Purpose : To assess the changes in quality of life (QOL) of patients after treatment of their Gravesˇä ophthalmopathy (GO). Materials and Methods : In this prospective, cross-sectional study, the GO-QOL questionnaire was completed by 67 subjects before and at least 6 months after steroid treatment (61 subjects, group 1) or optic neuropathy orbital decompression (6 subjects, group 2). Visual, psychosocial, education and counseling scores (higher score = better health), GO severity and clinical activity scores and minimal clinically important difference (MCID) were recorded and analyzed for correlation and statistical significance. A P-value <0.05 was considered statistically significant. Results : The mean age of patient enrolled in the study was 38.3 years, with 43 females (64.2%). The mean duration of thyroid dysfunction and GO were 40.1 and 26.5 months, respectively. Two treatment groups were similar for all the variables (0.06 < P < 0.9), except for higher mean age in the orbital decompression group (45.2 versus 37.7 years) (P = 0.03). Mean severity, activity, visual function and psychosocial function scores significantly improved in group 1 (steroid group) (P < 0.05, all cases). A significant improvement in clinical activity score and psychosocial scores occurred in group 2 (decompression group) (P < 0.05). MCID was achieved in two-thirds of the patients, with no significant difference between groups (P > 0.05). There was no significant effect of duration of thyroid disease and GO and severity and activity of GO on QOL scores either before or after treatment (P > 0.05, all cases). Conclusion : Steroid treatment and orbital decompression significantly improve the QOL in GO. Duration, severity and activity of GO did not have a significant impact on the QOL.
%K Eyelid Retraction
%K Gravesˇä Ophthalmopathy
%K Proptosis
%K Quality of Life
%U http://www.meajo.org/article.asp?issn=0974-9233;year=2011;volume=18;issue=1;spage=42;epage=47;aulast=Kashkouli