%0 Journal Article
%T Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma
%A Mehdi Dehghani
%A Vahid Mohammad Karimi
%J Middle East Journal of Cancer
%D 2012
%I Shiraz University of Medical Sciences
%X We report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than 30%, polyuria,and low urine specific gravity. This unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. The tubular functional disturbance appeared to be related to thepresence of lambda-type light chains. The patient was treated withdesmopressine without response. After one month of treatment with thalidomide and dexamethasone for myeloma there was a dramatic response with decreased urine output.
%K Nephrogenic diabetes insipidus
%K Multiple myeloma
%K Lambda light chain
%K Amyloidosis
%U http://mejc.sums.ac.ir/index.php/mejc/article/view/88/211