%0 Journal Article
%T Increased IL-17 and IL-6 Transcripts in Peripheral Blood Mononuclear Cells: Implication for a Robust Proinflammatory Response in Early Stages of Breast Cancer
%A Mansooreh Jaberipour
%A Rasoul Baharlou
%A Ahmad Hosseini
%A Abdolrasoul Talei
%J Middle East Journal of Cancer
%D 2011
%I Shiraz University of Medical Sciences
%X Background: Several recent studies demonstrated that transforming growth factor beta (TGF-¦Â), by stimulating T regulatory cells, and interleukins 6 and 17 (IL-6, IL-17), by inducing inflammatory reactions, may be critical factors in cancer pathogenesis. Methods: We used quantitative real-time polymerase chain reaction assays to quantify the expression of IL-17, IL-6 and TGF-¦Â mRNA in peripheral blood mononuclear cells and lymphocytes from draining lymph nodes of 60 women with breast cancer. The results were compared according to the patients¡¯ clinical or pathological status. Results: Higher amounts of IL-17 and IL-6 mRNA, but not TGF-¦Â transcripts, were found in patients compared to controls. There were no significant differences between patients with negative or positive nodes or with different histological grades or stages of disease. Conclusion: Most women in this analysis had stage I or II disease. We thus conclude that IL-17, a prominent proinflammatory cytokine, may play an important role in recruiting and infiltrating antitumor immune responses in early stages of breast cancer.
%K Breast cancer
%K Interleukin-6
%K Interleukin-17
%K Transforming growth factor beta
%U http://mejc.sums.ac.ir/index.php/mejc/article/view/44/117