%0 Journal Article
%T CALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern
%A Devi Sandhya
%A Goyal Manu
%A Ramakrishna N. V. S. S.
%A Murthy S
%J Indian Journal of Pathology and Microbiology
%D 2011
%I Medknow Publications
%X Rearrangements of the mixed lineage leukemia (MLL) gene at 11q23 commonly occur in infants with CALLA negative B lymphoblastic leukemia (B-ALL). Most often, these are detected by conventional karyotyping; however, fluorescent in-situ hybridization (FISH) with the help of a dual-color break-apart probe is used to identify cryptic translocations. When there is an MLL gene translocation, the usual FISH signal pattern is 1 red-1 green-1 yellow fusion signal pattern. We present a case of an infant with CALLA negative precursor B-ALL with a characteristic translocation t(4;11) (q21;q23), however, with an unusual MLL FISH signal pattern.
%K B lymphoblastic leukemia
%K CALLA negative
%K conventional karyotyping
%K fluorescent in-situ hybridization
%K mixed lineage leukemia gene
%U http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=176;epage=179;aulast=Devi