%0 Journal Article
%T Family-based association study of dopaminergic genes polymorphisms and EAS temperamental traits [Polimorfizmy w genach systemu dopaminergicznego a cechy temperamentu EAS ¨C rodzinne badanie asocjacyjne]
%A Dragan
%A Wojciech £¿.
%A Oniszczenko
%A W£¿odzimierz
%A Czerski
%A Piotr M.
%A Dmitrzak-W£¿glarz
%A Monika
%J Psychiatria Polska
%D 2013
%I Polskie Towarzystwo Psychiatryczne
%X Aim. The aim of the present study was to identify relations between several polymorphisms in dopamine genes (DRD2,DRD3, DRD4, SNAP-25, ANKK1and DAT1) and temperamental traits distinguished in the EAS theory. In this study the family-based method was used.Method. The study was run on 149 biological families with one or two children aged 3-12. Temperamental data were obtained using Buss and Plomin EAS-C Temperament Questionnaire.Results. Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found. Significant relationships of this trait with haplotypes in DAT1 and SNAP-25 genes was also identified. Conclusion. The data collected suggest that variability in dopamine genes may have impact on the development of temperamental shyness, which is recognized as a fear of strangers.
%K shyness
%K dopamine
%K temperament
%U http://www.psychiatriapolska.pl/uploads/images/PP_2_2013/185Dragan_PP2_2013.pdf