%0 Journal Article
%T MPO-ANCA associated crescentic glomerulonephritis with numerous immune complexes: case report
%A Ryuji Morizane
%A Konosuke Konishi
%A Akinori Hashiguchi
%A Hirobumi Tokuyama
%A Shu Wakino
%A Hiroshi Kawabe
%A Matsuhiko Hayashi
%A Koichi Hayashi
%A Hiroshi Itoh
%J BMC Nephrology
%D 2012
%I BioMed Central
%R 10.1186/1471-2369-13-32
%X A 78-year-old man presented with RPGN after a 7-year course of chronic proteinuria and hematuria with stable renal function. A blood examination showed a high titer of myeloperoxidase (MPO)-ANCA. A renal biopsy showed crescentic glomerulonephritis with abundant subepithelial, intramenbranous and subendothelial deposits by electron microscopy, leading to the diagnosis of ANCA-associated CGN superimposed on type 3 membranoproliferative glomerulonephritis (MPGN).This case is unique in that type 3 MPGN and MPO-ANCA-associated CGN coexisted, and no similar case has been reported to date. Because ANCA-associated CGN has a predilection for elderly individuals and primary type 3 MPGN is rarely seen in this age group, coincidental existence appears less likely. This case may confer valuable information regarding the link between immune complex and ANCA-associated CGN.
%K Myeloperoxidase-antineutrophil cytoplasmic antibody
%K Membranoproliferative glomerulonephritis
%K Immune complex
%K Rapidly progressive glomerulonephritis
%U http://www.biomedcentral.com/1471-2369/13/32/abstract