%0 Journal Article
%T Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis
%A Bianca Weinstock-Guttman
%A Murali Ramanathan
%A Karen Marr
%A David Hojnack
%A Ralph H.B. Benedict
%A Charity Morgan
%A Eluen A Yeh
%A Ellen Carl
%A Cheryl Kennedy
%A Justine Reuther
%A Christina Brooks
%A Kristin Hunt
%A Makki Elfadil
%A Michelle Andrews
%A Robert Zivadinov
%J BMC Neurology
%D 2012
%I BioMed Central
%R 10.1186/1471-2377-12-26
%X The objective was to evaluate the clinical correlates of venous anomalies indicative of CCSVI in£¿patients with MS.The original study enrolled 499 subjects; 163 HC, 289 MS, 21 CIS and 26 subjects with other neurological disorders who underwent a clinical examination and a combined Doppler and TCD scan of the head and neck. This analysis was restricted to adult subjects with MS (RR-MS: n£¿=£¿181, SP-MS: n£¿=£¿80 and PP-MS: n£¿=£¿12). Disability status was evaluated by using the Kurtzke Expanded Disability Status Scale (EDSS) and MS severity scale (MSSS).Disability was not associated with the presence (¡Ý2 venous hemodynamic criteria) or the severity of CCSVI, as measured with venous hemodynamic insufficiency severity score (VHISS). However, the severity of CCSVI was associated with the increased brainstem functional EDSS sub-score (p£¿=£¿0.002). In logistic regression analysis, progressive MS (SP-MS or PP-MS) vs. non-progressive status (including RR-MS) was associated with CCSVI diagnosis (p£¿=£¿0.004, OR£¿=£¿2.34, CI£¿=£¿1.3¨C4.2).The presence and severity of CCVSI in multiple sclerosis correlate with disease status but has no or very limited association with clinical disability.
%K Multiple sclerosis
%K Disease progression
%K Disability
%K Echo-color Doppler
%K Venous anomalies
%K CCSVI
%U http://www.biomedcentral.com/1471-2377/12/26/abstract