%0 Journal Article
%T Incidence of and risk factors for Motor Neurone Disease in UK women: a prospective study
%A Pat Doyle
%A Anna Brown
%A Valerie Beral
%A Gillian Reeves
%A Jane Green
%J BMC Neurology
%D 2012
%I BioMed Central
%R 10.1186/1471-2377-12-25
%X 1.3 million women from the UK Million Women Study, aged 56£¿years on average at recruitment, were followed up for incident and/or fatal MND using NHS hospital admission and mortality data. Adjusted relative risks were calculated using Cox regression models.During follow-up for an average of 9¡¤2£¿years, 752 women had a new diagnosis of MND. Age-specific rates increased with age, from 1¡¤9 (95% CI 1¡¤3 ¨C 2¡¤7) to 12¡¤5 (95% CI 10¡¤2 ¨C 15¡¤3) per 100,000 women aged 50¨C54 to 70¨C74, respectively, giving a cumulative risk of diagnosis with the disease of 1¡¤74 per 1000 women between the ages of 50 and 75£¿years. There was no significant variation in risk of MND with region of residence, socio-economic status, education, height, alcohol use, parity, use of oral contraceptives or hormone replacement therapy. Ever-smokers had about a 20% greater risk than never smokers (RR 1¡¤19 95% CI 1¡¤02 to 1¡¤38, p£¿=£¿0¡¤03). There was a statistically significant reduction in risk of MND with increasing body mass index (pfor trend£¿=£¿0¡¤009): obese women (body mass index, 30£¿kg/m2 or more) had a 20% lower risk than women of normal body mass index (20 to <25 Kg/m2)(RR 0¡¤78 95% CI 0¡¤65-0¡¤94; p£¿=£¿0¡¤03). This effect persisted after exclusion of the first three years of follow-up.MND incidence in UK women rises rapidly with age, and an estimated 1 in 575 women are likely to be affected between the ages of 50 and 75£¿years. Smoking slightly increases the risk of MND, and adiposity in middle age is associated with a lower risk of the disease.
%K Motor Neurone Disease
%K UK
%K Epidemiology
%K Incidence
%K Risk Factors
%K Smoking
%K Body Mass Index
%U http://www.biomedcentral.com/1471-2377/12/25/abstract