%0 Journal Article
%T Synthesis and stereochemistry of 6-membered ring phosphonates
%A Michael D. Pungente
%A Larry Weiler
%J QScience Connect
%D 2012
%I Bloomsbury Qatar Foundation Journals
%R 10.5339/connect.2012.2
%X Background: Organophosphorus compounds have important industrial and biomedical applications as pharmaceutical and agrochemical agents, as well as transition state analogs for the production of monoclonal antibodies. Methods: Two diastereomers of a 6-membered ring, cyclic phenyl phosphonate were synthesized in 8 steps from 1,3-butanediol. Results: The stereochemistry of the diastereomers was elucidated on the basis of H NMR nuclear Overhauser effects (NOE) difference experiments. Conclusions: Such cyclic phosphonates may have utility serving as transition state analogs for the production of monoclonal antibodies.
%U http://www.qscience.com/doi/pdf/10.5339/connect.2012.2