%0 Journal Article
%T GENE THERAPY: THE FOREFRONT OF MEDICINE
%A Hemen Das
%A A.Lateef
%A Pankaj Kumar
%A B.S.Chandel
%J Wayamba Journal of Animal Science
%D 2012
%I Wayamba University
%X The concept of transferring genes to tissues for clinical applications has been discussed for nearly half a century, but the ability to manipulate genetic material via recombinant DNA technology has brought this goal to reality. While originally conceived as a way to treat life-threatening disorders (inborn errors, cancers) refractory to conventional treatment, gene therapy is now considered for many non¨Clife-threatening conditions, including those adversely affecting a patientĄ¯s quality of life. The lack of suitable treatment has become a rational basis for extending the scope of gene therapy. This manuscript reviews the general methods by which genes are transferred as well as diverse examples of clinical applications (acquired tissue damage, upper gastrointestinal tract infection, autoimmune disease, systemic protein deficiency). Despite some well-publicized problems, gene therapy has made substantive progress, including tangible success, albeit much slower than was initially predicted. Although gene therapy is still at a fairly primitive stage, it is firmly science based. There is justifiable optimism that with increased patho-biological understanding and biotechnological improvements, gene therapy will become a standard part of clinical practice within 20 years
%U http://www.wayambajournal.com/paper.php?n=1342697090