%0 Journal Article
%T Radiotherapy in marginal zone lymphoma
%A Deinbeck Kristin
%A Geinitz Hans
%A Haller Bernhard
%A Fakhrian Khashayar
%J Radiation Oncology
%D 2013
%I BioMed Central
%R 10.1186/1748-717x-8-2
%X Purpose To evaluate the efficacy of radiotherapy (RT) for early-stage nodal and extranodal marginal zone lymphoma (MZL). Materials and methods Patients with stage I (n = 22) and stage II (n = 8) MZL, who were treated with RT were reviewed. The primary tumor localisation was in the orbita (n = 12), stomach (n = 8), head and neck other than the orbita (n = 8), breast (n = 1) and one case of marginal zone lymphoma of the skin (n = 1). The median radiotherapy dose was 40 Gy (5 to 45 Gy). Results The median follow-up time was 103 months. The 5-year overall survival and event-free survival rates were 85 ¡À 7% and 71 ¡À 9%, respectively. There was no infield recurrence. Recurrence occurred outside of the radiation field in six patients. The relapses were treated with salvage RT and had excellent local control (100%) at five years after salvage RT. Conclusions Localized extranodal MZL have an excellent prognosis following moderate-dose RT. RT is also an effective salvage therapy in cases of localized recurrence. Further clinical studies should evaluate the optimal dose for MZL.
%K Gastric lymphoma
%K MALT
%K Marginal zone lymphoma
%K Radiotherapy
%U http://www.ro-journal.com/content/8/1/2