%0 Journal Article
%T SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-[1,2,4]TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY
%A Ahmet £¿ZDEM£¿R
%A Zafer As£¿m KAPLANCIKLI
%A G¨¹lhan TURAN ZITOUNI
%A Mehlika Dilek ALTINTOP
%J Anadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology
%D 2011
%I Anadolu University
%X The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide deriva- tives (3a-j) were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides (1a-e) with appropriate 4H-[1,2,4]triazol-2-thione (2a-b). The chemical structures of the compounds were eluci- dated by elemental analyses, IR, 1H-NMR, 13C-NMR and FAB+-MS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomo- nas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organisms
%K Benzothiazole
%K Triazole
%K Antimicrobial activity
%U http://btd.anadolu.edu.tr/index.php/BTDC/article/viewFile/5/58