%0 Journal Article
%T The LIS study (Lyubertsy study on mortality rate in patients after acute myocardial infarction). Evaluation of drug therapy. Part 2. Influence of previous drug treatment on long-term life prognosis
%A S.Yu. Martsevich
%A M.L.Gynzburg
%A N.P. Kutishenko
%A A.D. Deev
%J Rational Pharmacotherapy in Cardiology
%D 2012
%I Rational Pharmacotherapy in Cardiology
%X Aim. To evaluate drug therapy received by patients who had survived acute myocardial infarction (AMI) in the framework of the AMI register (the ¡°LIS¡± study) and estimate this therapy influence on long-term outcomes of the disease.Material and methods. The total of 961 patients of 1133 enrolled in the ¡°LIS¡± study, were discharged from hospital. 191 patients had died during follow-up. 632 patients (who had survived and consented to visit out-patient clinic) underwent repeated examination (median of follow-up 1.6 [1.0; 2.4] years). Data about treatment before and during AMI were received from patient¡¯s charts; data about treatment after AMI were obtained from out-patient medical records.Results. Before reference AMI only a small number of the patients received the main drug groups (antiplatelet agents, ¦Â-blockers, ACE inhibitors, statins), at that ACE inhibitors were prescribed more often than the others. Use of ¦Â-blockers and ACE inhibitors before reference AMI significantly improved long-term life prognosis [relative risk (RR) 0.70 and 0.66, respectively]. Rate of the main drug groups prescribed in hospital was rather high with the exception of thrombolytics (less than 10%). Thrombolytics, ¦Â-blockers and antiplatelet agents prescribed in hospital significantly improved long-term life prognosis of patients (RR 0.42, 0.65 and 0.58 respectively). At the second visit (according to data of out-patient medical records) rate of antiplatelet agents, ACE inhibitors, ¦Â-blockers and statins prescription exceeded 60%.Conclusion. Very low prevalence of adequate drug therapy preceding AMI determines high mortality rate among survived acute stage of myocardial infarction patients in long-term period.
%K acute myocardial infarction
%K register
%K long-term life prognosis
%K evaluation of drug treatment
%U http://www.rpcardio.com/archive/article.php?ID=3756