%0 Journal Article
%T Diagnostic accuracy of lugol chromoendoscopy in the oesophagus in patients with head and neck cancer Seguridad diagn¨®stica de la cromoendoscopia con lugol en el es¨®fago de pacientes con c¨¢ncer de cabeza y cuello
%A Rita Carvalho
%A Miguel Areia
%A Daniel Brito
%A Sandra Saraiva
%J Revista Espa£¿ola de Enfermedades Digestivas
%D 2013
%I The Spanish Society of Digestive Pathology
%X Background and aim: patients with head and neck squamous cell malignancies have a higher risk of oesophageal squamous cell carcinomas. Lugol chromoendoscopy in oesophagus is a simple technique with a high diagnostic yield in premalignant lesions. The objective was to analyze its diagnostic accuracy in dysplasia and carcinoma of the oesophagus in high-risk patients. Methods: prospective study from April/2008 to January/2012 using lugol chromoendoscopy with biopsies of suspicious lugol voiding areas ¡Ý 5 mm. Patients with head and neck malignancies were included, except the ones with iodine allergy, oesophageal varices and contra-indications to standard endoscopy. The reference method was histopathology. Results: 89 patients were enrolled (mean age 62.8 ¡À 13.3 years, 87 % men). Primary tumour was located in oropharynx in 37 (41.6 %), in oral cavity in 29 (32.6 %) and in the larynx in 23 (25.8 %) cases. 40.4 % patients had previous treatments and 87 % reported alcohol or tobacco addition. All exams performed without anaesthesia or complications. Nine suspicious lugol voiding areas were observed and biopsied. Histopathological analysis revealed high-grade dysplasia in 2 (2.2 %) and inflammation or normal findings in the others. The sensitivity and specificity for detecting high-grade dysplasia were 100 % and 92 % (95 % CI: 87-97), respectively. Diagnostic accuracy of the test was 92 % (95 % CI: 86-98). Conclusion: lugol staining of the oesophagus during endoscopy seems to be a feasible, safe and justified procedure in high-risk population as it enhances the detection of premalignant lesions.
%K Oesophageal cancer
%K Squamous cell carcinoma
%K Lugol solution
%K Gastrointestinal Endoscopy
%K Chromoendoscopy
%U http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000200004