%0 Journal Article
%T Influence of quinapril on the regulatory-adaptive status of patients with chronic heart failure HYHA class I: results of not comparative study
%A V.G. Tregubov
%A S.G. Kanorskiy
%A V.M. Pokrovskiy
%J Rational Pharmacotherapy in Cardiology
%D 2012
%I Rational Pharmacotherapy in Cardiology
%X Aim.To assess effects of quinapril on the regulatory-adaptive status (RAS) in patients with chronic heart failure (CHF) NYHA class 1 and arterial hypertension (HT).Material and methods.Patients (n=49) with CHF NYHA class I and HT stage I¨CII (25 men and 24 women, aged 52.5¡À8.4 years) were included into an open noncomparative study. A cardio-respiratory synchronization (CRS) test, 6 minute walk test, treadmill test with evaluation of the maximal oxygen uptake during exercise, ambulatory blood pressure monitoring, echocardiography, determination of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) plasma level were performed at baseline and after 6 months of quinapril therapy.Results.The quinapril treatment (average daily dose 17.3¡À7.9 mg) improved myocardium structural and functional parameters, increased the exercise tolerance, reduced neurohumoral activity, improved the RAS according to CRS test: increase in synchronization range of cardiorespiratory cycles per minute from 8.0¡À2.1 to 11.0¡À2.5 (¦¤27.3%; p<0.01), as well as RAS index from 52.6¡À7.8 to 89.7¡À8.9 (¦¤41.4%; p<0.01), and decrease in the duration of CRS development at the minimal border of cardiac cycles from 15.5¡À3.5 to 12.9¡À2.8 (¦¤15.8%; p<0.01).Conclusion. Quinapril has a positive effect on the RAS in patients with CHF NYHA class I and HT of stage I¨CII.
%K chronic heart failure
%K quinapril
%K cardio-respiratory synchronism
%K regulatory-adaptive status.
%U http://www.rpcardio.com/archive/article.php?ID=3646