%0 Journal Article
%T Chromosomal integration of an avian oncogenic herpesvirus reveals telomeric preferences and evidence for lymphoma clonality
%A Charmaine M Robinson
%A Henry D Hunt
%A Hans H Cheng
%A Mary E Delany
%J Herpesviridae
%D 2010
%I BioMed Central
%R 10.1186/2042-4280-1-5
%X Here we employed high-resolution multi-color fluorescence in situ hybridization (FISH) to show integration of MDV at the telomeres of chicken chromosomes. Cytogenomic mapping of the chromosomal integrations allowed us to examine the clonal relationships among lymphomas within individuals, whereas analysis of tumors from multiple individuals indicated the potential for chromosomal preferences.Our data highlight that substantive genome-level interactions between the virus and host exist, and merit consideration for their potential impact and role in key aspects of herpesvirus pathobiology including infection, latency, cellular transformation, latency-breaks and viral evolution.Herpesviruses are a large group of DNA viruses that cause disease in many organisms [1,2]. The ability of herpesviruses to occupy diverse biological niches, the wide range of cell types targeted for primary infection and latency, along with acute and chronic infection symptoms, contribute to the significance and relevance of herpesvirus research. In particular, human herpesviruses are a major public health concern due to the prevalence of such viruses within and among populations worldwide and the associated pathologies. Two of the eight disease-causing human herpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma virus (KSHV), are associated with neoplastic transformation. A closely related avian herpesvirus, Marek's disease virus (MDV; family Herpesviridae, genus Mardivirus, species Gallid herpesvirus 2) also exhibits oncogenic properties inducing lymphoid tumors in chickens.MDV rapidly infects B cells and subsequently transforms T cells during pathogenesis of the highly contagious neoplastic disease of chickens known as Marek's disease (MD). Since discovery [3], MD has been extensively studied and utilized as a valuable biomedical model for human herpesvirus infection and viral induced malignancies [4,5]. MDV is of great concern in agriculture, causing large economic losses as well as im
%U http://www.herpesviridae.org/content/1/1/5