%0 Journal Article
%T Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis Efecto de los probi車ticos en los s赤ntomas del s赤ndrome del intestino irritable: un meta-an芍lisis actualizado
%A Mar赤a Ortiz-Lucas
%A Tobias Aurelio
%A Pablo Saz
%A Juan Jos谷 Sebasti芍n
%J Revista Espaˋola de Enfermedades Digestivas
%D 2013
%I The Spanish Society of Digestive Pathology
%X Background and objectives: immune system alteration in irritable bowel syndrome (IBS) patients may be modulated by probiotics. We assessed the efficacy of some probiotic species in alleviating characteristic IBS symptoms. Material and methods: a meta-analysis of all identified randomized controlled trials comparing probiotics with placebo in treating IBS symptoms was performed with continuous data summarized using standardized mean differences (SMDs) with 95% confidence intervals (95% CIs), where appropriate. The random-effects model was employed in cases of heterogeneity; otherwise, fixed-effects models were used. Results: meta-analysis was performed with 10 of 24 studies identified as suitable for inclusion. Probiotics improved pain scores if they contained Bifidobacterium breve (SMD, -0.34; 95% CI, -0.66; -0.02), Bifidobacterium longum (SMD, -0.48; 95% CI, -0.91; -0.06), or Lactobacillus acidophilus (SMD, -0.31; 95% CI, -0.61; -0.01) species. Distension scores were improved by probiotics containing B. breve (SMD, -0.45; 95% CI, -0.77; -0.13), Bifidobacterium infantis, Lactobacillus casei, or Lactobacillus plantarum (SMD, -0.53; 95% CI, -1.00; -0.06) species. All probiotic species tested improved flatulence: B. breve (SMD, -0.42; 95% CI, -0.75;-0.10), B. infantis, L. casei, L. plantarum (SMD, -0.60; 95% CI, -1.07; -0.13), B. longum, L. acidophilus, Lactobacillus bulgaricus, and Streptococcus salivarius ssp. thermophilus (SMD, -0.61; 95% CI, -1.01; -0.21). There was not a clear positive effect of probiotics concerning the quality of life. Conclusions: some probiotics are an effective therapeutic option for IBS patients, and the effects on each IBS symptom are likely species-specific. Future studies must focus on the role of probiotics in modulating intestinal microbiota and the immune system while considering individual patient symptom profiles. Antecedentes y objetivos: la alteraci車n del sistema inmune en los pacientes con s赤ndrome del intestino irritable (SII) podr赤a modularse por el efecto de los probi車ticos. Se evalu車 la eficacia de algunas especies de probi車ticos en el alivio de s赤ntomas caracter赤sticos del SII. Material y m谷todos: se realiz車 un meta-an芍lisis de todos los ensayos cl赤nicos aleatorios identificados donde se comparaba los probi車ticos con el placebo en el tratamiento de s赤ntomas del SII. El meta-an芍lisis se realiz車 empleando datos continuos empleando diferencias de medias estandarizadas (DME) con intervalos de confianza del 95% (IC 95%). Se emple車 el modelo de efectos aleatorios en casos de heterogeneidad, si no, el modelo de efectos f
%K Probi車ticos
%K S赤ndrome del intestino irritable
%K Sistema inmune
%K Meta-an芍lisis
%K Probiotics
%K Irritable bowel syndrome
%K Immune system
%K Meta-analysis
%U http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000100005