%0 Journal Article
%T Granulocytic sarcoma of the small bowel, greater omentum and peritoneum associated with a CBF¦Â/MYH11 fusion and inv(16) (p13q22): a case report
%A Paloma ¨¢lvarez
%A Carmen A Navascu¨¦s
%A Carlos Ordieres
%A Mar¨ªa Pipa
%A Iv¨¢n F Vega
%A Pablo Granero
%A Jos¨¦ A Alvarez
%A Manuel Rodr¨ªguez
%J International Archives of Medicine
%D 2011
%I BioMed Central
%R 10.1186/1755-7682-4-3
%X We present a rare case of GS of the small bowel, greater omentum and peritoneum, which caused obstruction, in a patient with AML associated with a CBF¦Â/MYH11 fusion gene and an inv(16) (p13q22). In this patient there was only mild myeloid hyperplasia in bone marrow aspiration but molecular analysis identified a CBF¦Â-MYH11 fusion and inv(16) (p13;q22).Because of its nonspecific clinical and radiologic findings, this entity can be misdiagnosed and can mimic other solid neoplasms, making it a diagnostic challenge. In a GS with no or minimal morphological changes in bone marrow aspiration it is very important to perform a cytogenetic analysis to benefit from the diagnosis and therapeutic strategy.Myeloid sarcoma represents an extramedular tumour of myeloblasts and/or immature myeloid cells [1]. Previous terms used to describe this entity include chloroma, extramedullary myeloid tumour, and granulocytic sarcoma (GS). Chloroma was the initial term used to describe these neoplasms, due to gross greenish appearance identified in some lesions [2]. The World Health Organization classification of haematopoietic tumours divides myeloid sarcoma into two major categories [1]. The more common form is GS, composed mainly of myeloblasts, neutrophils, and myeloid precursors. The less common form is monoblastic sarcoma, which is tipically composed of monoblasts and is associated with acute monoblastic leukemia. GS can occur in virtually any anatomic site, with a particular predilection for skin, bone/spine, lymph nodes, soft tissue and genitourinary tract [2,3]. Involvement of gastrointestinal tract is uncommon (7%) and the most frequently involved region in this system is the small bowel (10%) [2,4].GS may present in association with acute myeloid leukemia (AML), either as an initial presentation or as a relapse. It may also signal impending blast crisis in the setting of a myeloproliferative disorder or leukemic transformation in myelodysplastic syndrome. Less commonly, it may also
%U http://www.intarchmed.com/content/4/1/3