%0 Journal Article
%T Improvement of refractory migraine headache by propofol: case series
%A Hassan Soleimanpour
%A Aliakbar Taheraghdam
%A Rouzbeh Rajaei Ghafouri
%A Ali Taghizadieh
%A Karim Marjany
%A Maryam Soleimanpour
%J International Journal of Emergency Medicine
%D 2012
%I BioMed Central
%R 10.1186/1865-1380-5-19
%X Intravenous propofol was prescribed (10£¿mg every 5£¿min) for eight patients with intractable migraine headaches visiting the Emergency Department. The average pain score experienced by patients was recorded using the Visual Analogue Scale at the beginning of the treatment procedure and following the injection for 30£¿min (5-min intervals). The patients¡¯ reported pain scores decreased significantly (P£¿=£¿0.01) from 8.87£¿¡À£¿0.83 (CI: 8.17, 9.57) to 1.12£¿¡À£¿0.83 (CI: 0.43, 1.82) before and 30£¿min following the injection.It seems that in the treatment of intractable migraine headaches, GABAergic receptors, compared to the normal conditions, have a lower activity status.Because of the high tendency of propofol to GABAergic receptors, it probably changes this physiological condition by activating the receptors, which results in a significant pain reduction.
%K Propofol
%K Migraine headache
%K Visual analogue scale
%K Emergency department
%K GABAergic receptors
%U http://www.intjem.com/content/5/1/19/abstract