%0 Journal Article
%T Angiog¨¦nese e Arteriog¨¦nese na Doen a Arterial Perif¨¦rica Angiogenesis and Arteriogenesis in Peripheral Arterial Disease
%A Daniel Brand£¿o
%A Carla Costa
%A Armando Mansilha
%J Angiologia e Cirurgia Vascular
%D 2012
%I Sociedade Portuguesa de Angiologia e Cirurgia Vascular
%X Em adapta  o ¨¤ obstru  o da ¨¢rvore arterial e consequente isquemia, os organismos induzem os processos arteriog¨¦nico e angiog¨¦nico no sentido de melhorar o aporte sangu¨ªneo aos tecidos. Contudo, 25% dos doentes com doen a arterial perif¨¦rica (DAP) v o sofrer agravamento da sua condi  o isqu¨¦mica aos cinco anos, sugerindo insufici¨ºncia dos processos adaptativos. Estes mecanismos s o extremamente complexos e resultam da interac  o adequadamente coordenada de m¨²ltiplas mol¨¦culas com c¨¦lulas espec¨ªficas. O estudo da variabilidade interindividual nas mol¨¦culas envolvidas nos mecanismos vasculares de adapta  o ¨¤ isquemia poder¨¢ provavelmente possibilitar a identifica  o de biomarcadores com capacidade progn¨®stica n o s¨® em rela  o ¨¤ evolu  o da doen a, mas tamb¨¦m ¨¤ resposta ¨¤s terap¨ºuticas institu¨ªdas. In adaptation to arterial obstruction and consequent ischemia, organisms induce the arteriogenic and angiogenic mechanisms in order to improve blood supply to tissues. However, 25% of the patients with peripheral arterial disease will have a deterioration of their condition, suggesting failure of the adaptative processes. These mechanisms are extremely complex, resulting from the interaction of multiple molecules suitably coordinated with specific cells. The study of interindividual variability in the molecules involved in the vascular adaptive mechanisms to ischemia could probably enable the identification of prognostic biomarkers not only for the disease evolution, but also for the response to therapeutic approaches.
%K doen a arterial perif¨¦rica
%K arteriog¨¦nese
%K angiog¨¦nese
%K Peripheral arterial disease
%K arteriogenesis
%K angiogenesis
%K biomarkers
%U http://www.scielo.oces.mctes.pt/scielo.php?script=sci_arttext&pid=S1646-706X2012000200001