%0 Journal Article
%T Amn¨¦sie ant¨¦rograde cons¨¦cutive ¨¤ l¡¯absorption de MDMA et d¡¯alcool : ¨¤ propos d¡¯un cas Anterograde amnesia following MDMA and alcohol absorption: report of a case
%A Sastre Caroline
%A Ch¨¨ze Marjorie
%A Baillif-Couniou Val¨¦rie
%A Deveaux Marc
%J Annales de Toxicologie Analytique
%D 2012
%I 
%R 10.1051/ata/2011136
%X Objectifs : Les auteurs rapportent un cas original d¡¯amn¨¦sie ant¨¦rograde cons¨¦cutive ¨¤ l¡¯absorption concomitante d¡¯alcool et de MDMA. Patients et m¨¦thodes : Une jeune femme de 20 ans pr¨¦sente, au d¨¦cours d¡¯une soir¨¦e o¨´ elle aurait consomm¨¦ de l¡¯alcool et de l¡¯ecstasy, une amn¨¦sie ant¨¦rograde totale jusqu¡¯au lendemain matin. Le dosage de l¡¯alcool dans le sang et l¡¯urine est r¨¦alis¨¦ par HS-GC-FID ; le dosage des amph¨¦tamines et mol¨¦cules apparent¨¦es est effectu¨¦ dans ces m¨ºmes pr¨¦l¨¨vements par GC-MS et LC-MS/MS. La recherche des produits pouvant ¨ºtre utilis¨¦s lors d¡¯une soumission chimique est r¨¦alis¨¦e dans les cheveux par GC-MS/MS et LC-MS/MS. R¨¦sultats : Le sang et l¡¯urine sont pr¨¦lev¨¦s 36 heures apr¨¨s. La recherche de l¡¯¨¦thanol est n¨¦gative dans le sang et l¡¯urine. La MDMA et la MDA ont ¨¦t¨¦ identifi¨¦es au niveau sanguin et urinaire. Dans les cheveux, la MDMA et la MDA ont ¨¦t¨¦ mises en ¨¦vidence ¨¤ des concentrations respectives de 602 et 42 pg/mg uniquement au niveau du segment correspondant ¨¤ la p¨¦riode des faits. Conclusion : Il s¡¯agit d¡¯un cas original d¡¯amn¨¦sie ant¨¦rograde secondaire ¨¤ l¡¯association alcool-MDMA. Il confirme la n¨¦cessit¨¦ d¡¯¨¦tudier de fa on plus approfondie les effets de l¡¯association MDMA-alcool chez l¡¯Homme. Objectives: The authors report an unusual case of anterograde amnesia after concurrent ingestion of alcohol and MDMA. Patients and methods: A 20-year-old woman, after ingesting alcohol and ecstasy during the course of an evening, was reported to have suffered from anterograde amnesia until the next morning. Alcohol determination in blood and urine was performed by HS-GC-FID, while amphetamines were detected by GC-MS and LC-MS/MS. Hair analysis for the determination of drugs involved in drug-facilitated crimes was performed by GC-MS and LC-MS/MS. Results: Blood and urine were sampled 36 hours after the event. Alcohol was not detected in blood or urine. MDMA and MDA were identified in both blood and urine. MDMA and MDA were detected in hair at concentrations of 602 and 42 pg/mg, respectively, only in the segment corresponding to the period of the event. Conclusion: This is an unusual case of anterograde amnesia following concurrent use of alcohol and MDMA. This case underlines that it could be of great interest to study in more detail the effects of MDMA and alcohol in humans when taken concurrently.
%K MDMA
%K alcool
%K amn¨¦sie ant¨¦rograde
%K soumission chimique
%K MDMA
%K alcohol
%K anterograde amnesia
%K drug-facilitated crime
%U http://dx.doi.org/10.1051/ata/2011136