%0 Journal Article
%T Tutorial on Drug Development for Central Nervous System
%A Jungsu Kim
%A Hyejin Yoon
%J Interdisciplinary Bio Central
%D 2010
%I IBC
%X Many neurodegenerative diseases, such as Alzheimer¡¯s and Parkinson¡¯s disease, are devastating disorders that affect millions of people worldwide. However, the number of therapeutic options remains severely limited with only symptomatic management therapies available. With the better understanding of the pathogenesis of neurodegenerative diseases, discovery efforts for disease-modifying drugs have increased dramatically in recent years. However, the process of translating basic science discovery into novel therapies is still lagging behind for various reasons. The task of finding new effective drugs targeting central nervous system (CNS) has unique challenges due to blood-brain barrier (BBB). Furthermore, the relatively slow progress of neurodegenerative disorders create another level of difficulty, as clinical trials must be carried out for an extended period of time. This review is intended to provide molecular and cell biologists with working knowledge and resources on CNS drug discovery and development.
%K drug development
%K blood-brain barrier
%K drug toxicity
%K drug safety
%K drug screening
%K neurodegenerative diseases
%U http://www.ibc7.org/article/journal_v.php?sid=231&page=1