%0 Journal Article
%T Comparison of response to 2-years¡¯ growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observational studies
%A Peter A Lee
%A Lars S£¿vendahl
%A Isabelle Oliver
%A Maith¨¦ Tauber
%A Oliver Blankenstein
%A Judith Ross
%A Marta Snajderova
%A Viatcheslav Rakov
%A Birgitte T£¿nnes Pedersen
%A Henrik Thybo Christesen
%J International Journal of Pediatric Endocrinology
%D 2012
%I BioMed Central
%R 10.1186/1687-9856-2012-22
%X Analysis of auxologic data from two ongoing prospective observational studies, NordiNet£¿ International Outcomes Study (NordiNet£¿ IOS) and NovoNet£¿/American Norditropin£¿ Studies: Web-enabled Research (ANSWER) Program£¿.4,582 children aged <18£¿years were included: IGHD, n£¿=£¿3,298; SGA, n£¿=£¿678; ISS, n£¿=£¿334; and MPHD, n£¿=£¿272. After two years¡¯ GH treatment, change in height standard deviation score (SDS) was +1.03 in SGA and +0.84 in ISS vs. +0.97 in IGHD (p£¿=£¿0.047; p£¿<£¿0.001 vs. IGHD, respectively). Height gain was comparable between IGHD and MPHD. In pre-pubertal children vs. total population, height SDS change after two years was: IGHD, +1.24 vs. +0.97; SGA, +1.17 vs. +1.03; ISS, +1.04 vs. +0.84; and MPHD, +1.16 vs. +0.99 (all p£¿<£¿0.001).After two years¡¯ GH treatment, change in height SDS was greater in SGA and less in ISS, compared with IGHD; the discrepancy in responses may be due to the disease nature or confounders (i.e. age). Height SDS increase was greatest in pre-pubertal children, supporting early treatment initiation to optimize growth outcomes.
%K Isolated growth hormone deficiency
%K Small for gestational age
%K Multiple pituitary hormone deficiency
%K Idiopathic short stature
%K Puberty
%K Norditropin£¿
%U http://www.ijpeonline.com/content/2012/1/22/abstract