%0 Journal Article
%T Impaired endothelial function in pediatric patients with turner syndrome and healthy controls: a case-control study
%A Clodagh S O'Gorman
%A Catriona Syme
%A Tim Bradley
%A Jill Hamilton
%A Farid H Mahmud
%J International Journal of Pediatric Endocrinology
%D 2012
%I BioMed Central
%R 10.1186/1687-9856-2012-5
%X A cross-sectional case-control study of Turner Syndrome girls and healthy controls. Subjects underwent fasting insulin and glucose with calculation of HOMA-IR, fasting lipid profile, anthropometrics, and EF testing using peripheral arterial tonometry (PAT). Subjects, aged 10-18 years, had karyotype-confirmed Turner Syndrome; growth hormone (GH), thyroxine and estrogen use were not exclusion criteria. Controls were age- and BMI-matched healthy girls. Fifteen Turner Syndrome and 15 controls were recruited.Turner Syndrome girls had lower height, higher HDL and higher waist:height ratio than controls. PAT-hyperemia ratio (RH-PAT) scores were lower in Turner Syndrome (1.64 ¡À 0.34 vs. 2.08 ¡À 0.32, p = 0.002) indicating impaired EF. Among Turner Syndrome, RH-PAT did not vary with estrogen therapy or with karyotype 45,XO compared with other karyotypes. However, endothelial function was better in GH-treated compared with GH-untreated Turner Syndrome (1.80 ¡À 0.36 vs. 1.4 + 0.22, p = 0.02) although there were no differences in HOMA-IR, adiponectin or IGF-1.Girls with Turner Syndrome exhibit impaired endothelial function compared with controls, which may explain higher risk for vascular disease. GH may protect endothelial function in Turner Syndrome.Turner Syndrome, a common genetic disorder affecting 1 in 2500 live-born females, is caused by complete or partial loss of ¡Á chromosome [1]. Despite significant advances in diagnosis and treatment in pediatric settings, Turner Syndrome patients experience high rates of cardiovascular disease such that adult females with Turner Syndrome have 3.47 and 2.21 standardized mortality ratios of coronary and cerebrovascular death respectively [2]. The majority of this excess mortality risk encompasses non-congenital circulatory disease [3]. However, this relates to underlying congenital structural and functional arterial abnormalities, which predispose these patients to aortic dilatation and aneurysm [4]. Additionally, Turner Syndrome patien
%K Turner syndrome
%K Endothelial function
%K Adolescents
%K Pediatrics
%U http://www.ijpeonline.com/content/2012/1/5