%0 Journal Article
%T The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats
%A Aliakbar Rajabzadeh
%A Alireza Ebrahimzadeh Bideskan
%A Alireza Fazel
%A Mojtaba Sankian
%A Houshang Rafatpanah
%A Hossein Haghir
%J Journal of Biomedical Science
%D 2012
%I BioMed Central
%R 10.1186/1423-0127-19-56
%X Forty timed-pregnant Wistar rats were divided into four groups: A) Kind+/Seiz+, pregnant kindled (induced two weeks prior to pregnancy) rats that received repeated intraperitoneal (i.p.) pentylenetetrazol, PTZ injections on gestational days (GD) 14-19; B) Kind-/Seiz+, pregnant non-kindled rats that received PTZ injections on GD14-GD19; C) Kind+/Seiz-, pregnant kindled rats that did not receive any PTZ injections; and D) Kind-/Seiz-, the sham controls. Following birth, the pups were sacrificed on PD1 and PD14, and PSA-NCAM expression and localization in neonates¡¯ hippocampi were analyzed by Western blots and immunohistochemistry.Our data show a significant down regulation of hippocampal PSA-NCAM expression in the offspring of Kind+/Seiz+ (p£¿=£¿0.001) and Kind-/Seiz+ (p£¿=£¿0.001) groups compared to the sham control group. The PSA-NCAM immunoreactivity was markedly decreased in all parts of the hippocampus, especially in the CA3 region, in Kind+/Seiz+ (p£¿=£¿0.007) and Kind-/Seiz+ (p£¿=£¿0.007) group¡¯s newborns on both PD1 and 14.Our findings demonstrate that maternal seizures but not kindling influence the expression of PSA-NCAM in the offspring¡¯s hippocampi, which may be considered as a factor for learning/memory and cognitive impairments reported in children born to epileptic mothers.
%K Maternal Seizure
%K Polysialylated Neural Cell Adhesion Molecule
%K Kindling
%K Rat Hippocampus
%U http://www.jbiomedsci.com/content/19/1/56/abstract