%0 Journal Article
%T Abnormal cholesterol processing in Alzheimer's disease patient's fibroblasts
%A Franck Dufour
%A Wei-Qin Zhao
%A Lakshmi Ravindranath
%A Daniel L. Alkon
%J Neurobiology of Lipids
%D 2003
%I 
%X Cholesterol has recently received attention as a potentially important factor in Alzheimer's disease (AD) etiology. Caveolin, which binds cholesterol, plays a prominent role in cellular cholesterol transport. Here, we found a higher level of cholesterol and caveolin in the caveolae-enriched fractions prepared from AD patients' fibroblasts compared with age and sex matched controls (AC). Furthermore, the cross-linking activation of the prion protein, which is known to link to signal transduction of caveolin, is altered in AD fibroblasts. Our results suggest a dysregulation of cholesterol processing in AD fibroblasts which may contribute to the pathogenesis of AD.
%K Alzheimer's disease
%K amyloid beta precursor
%K APP
%K Down syndrome
%K etiology
%K lipids
%K lipoprotein
%K neurodegeneration marker
%K secretase
%K caveolin
%K caveolae
%K membrane
%K cell culture
%K human
%K non-neuronal tissue
%K neurodegenerative disease
%K signal transduction
%K prion
%K PKC
%K cross-linking
%K fractioning
%K biochemistry
%K triton
%U http://neurobiologyoflipids.org/content/1/7/