%0 Journal Article
%T Amyloid precursor protein regulates brain cholesterol metabolism
%A Radosveta Koldamova
%J Neurobiology of Lipids
%D 2007
%I 
%X There is a scientific evidence, suggesting that amyloid precursor protein (APP) processing and Alzheimer's (AD) amyloid beta generation are regulated by cholesterol. Latest study by Liu et al. published in Neuron (56:66-78, 2007) shines a new light on the connection between cholesterol metabolism and APP processing. At this time the story is reversed - now it appears that APP proteolytic fragments are regulating cholesterol levels in brain and inside the cells.
%K Alzheimer's disease
%K amyloid precursor protein
%K APP
%K gamma secretase
%K lipoprotein receptor
%K HDL
%K cholesterol
%K AICD
%K Abca1
%K LXR
%K Apolipoprotein E
%K Apo E
%U http://neurobiologyoflipids.org/content/6/1/