%0 Journal Article
%T Validation of actigraphy to assess circadian organization and sleep quality in patients with advanced lung cancer
%A James F Grutsch
%A Patricia A Wood
%A Jovelyn Du-Quiton
%A Justin L Reynolds
%A Christopher G Lis
%A Robert D Levin
%A Mary Ann Daehler
%A Digant Gupta
%A Dinah Quiton
%A William JM Hrushesky
%J Journal of Circadian Rhythms
%D 2011
%I BioMed Central
%R 10.1186/1740-3391-9-4
%X This cross-sectional and case control study was conducted in 84 patients with advanced non-small cell lung cancer in a hospital setting for the patients at Midwestern Regional Medical Center (MRMC), Zion, IL, USA and home setting for the patients at WJB Dorn Veterans Affairs Medical Center (VAMC), Columbia, SC, USA. Prior to chemotherapy treatment, each patient's sleep-activity cycle was measured by actigraphy over a 4-7 day period and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire.The mean age of our patients was 62 years. 65 patients were males while 19 were females. 31 patients had failed prior treatment while 52 were newly diagnosed. Actigraphy and PSQI scores showed significantly disturbed daily sleep-activity cycles and poorer sleep quality in lung cancer patients compared to healthy controls. Nearly all actigraphic parameters strongly correlated with PSQI self-reported sleep quality of inpatients and outpatients.The correlation of daily activity/sleep time with PSQI-documented sleep indicates that actigraphy can be used as an objective tool and/or to complement subjective assessments of sleep quality in patients with advanced lung cancer. These results suggest that improvements to circadian function may also improve sleep quality.Living organisms use circadian (about 24-hour) oscillators and environmental cues to adjust the dynamics of their physiological/behavioral processes to critical phases of the geophysical day [1,2]. Preclinical and clinical data show that circadian organization diminishes with accelerating tumor growth and accurately predicts poor prognosis, while restoring normal circadian function improves quality of life and enhances the survival benefits of chemotherapy [3-7].Satisfying sleep is an important sign of a robust and well-entrained endogenous circadian time structure. Poor nighttime sleep quality is associated with reduced quality of life and unremitting daytime fatigue. Each of these traits is
%U http://www.jcircadianrhythms.com/content/9/1/4