%0 Journal Article
%T Inhibition of Immediate-Type Allergic Reaction by 4-Arylcoumarin
%A Thongchai Taechowisan
%A Chunhua Lu
%A Yuemao Shen
%A Saisamorn Lumyong
%J Research Journal of Immunology
%D 2008
%I 
%X We studied the effect of 4-Arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as pretreatment, at concentrations ranging from 0.001 to 1 g kg1, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore, MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-¦Á and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions.
%K 4-arylcoumarins
%K immediate-type allergic reaction
%K mast cells
%K tumor necrosis factor-¦Á
%K interleukin-6
%U http://docsdrive.com/pdfs/ansinet/rji/2008/1-9.pdf