%0 Journal Article
%T Design, synthesis and antimicrobial screening of s-Triazinyl piperazine and piperidine derivatives
%A Rahul V. Patel
%A Premlata Kumari
%A K. H. Chikhalia
%J International Journal of Advances in Pharmaceutical Sciences
%D 2011
%I 
%R 10.5138/194
%X A series of ten 2,4,6-trisubstituted s-triazines have been synthesized selectively with nucleophilic reagents such as 4-amino benzonitrile, 8-hydroxy quinoline and different piperazine as well as piperidine substituents on the C-6 position of s-triazine ring. The title compounds were then examined for their in vitro microbial activity against 2 gram ¨CVe bacteria (E. Coli, P. Aeruginosa), 2 gram +Ve bacteria (S. Aerues, B. subtilis) and 2 fungal species (C. Albicans and A. niger). The most of the synthesized compounds have shown potent anti-bacterial and anti-fungal activities. Structure of final scaffolds has been affirmed by means of IR, 1H NMR, 13C NMR and elemental analysis. Keywords: 2,4,6-trichloro-1,3,5-triazine, 8-hydroxy quinoline, 4-amino benzonitrile, anti microbial activity.
%K 2
%K 4
%K 6-trichloro-1
%K 3
%K 5-triazine
%K 8-hydroxy quinoline
%K 4-amino benzonitrile
%K anti microbial activity.
%U http://www.arjournals.org/index.php/ijaps/article/view/194