%0 Journal Article
%T Development and validation of spectrophotometric method for estimation of anastrozole bulk and pharmaceutical dosage formulation
%A Sathis Kumar D
%A Harani A
%A Rohit Reddy T
%A Sucharitha G
%J International Journal of Advances in Pharmaceutical Sciences
%D 2011
%I 
%R 10.5138/184
%X A simple, precise and accurate method was developed and validated by using a simple solvent system for anastrozole bulk and tablet dosage form. In the developed method, water and ethanol are used as solvents. The ¦Ëmax was determined to be 221nm. The procedure was validated as per ICH rules for Accuracy, Precision, Detection limit, Linearity, Reproducibility and Quantitation limit. The linearity concentration range was 40-60¦Ìg/mL with the correlation coefficient of 0.9971. The percentage recovery for anastrozole was found to be 98.6 to 100.8%. Limit of detection and limit of quantitation values were found to be 1¦Ìg/mL and 3¦Ìg/mL. The method has been successfully used to analyze commercial solid dosage containing 1mg of anastrozole with good recoveries and proved to be robust. Keywords: Anastrozole, Spectrophotometer, Method development, Validation
%K Anastrozole
%K Spectrophotometer
%K Method development
%K Validation
%U http://www.arjournals.org/index.php/ijaps/article/view/184