%0 Journal Article
%T M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding
%A Selhorst Philippe
%A Grupping Katrijn
%A Tong Tommy
%A Crooks Ema T
%J Retrovirology
%D 2013
%I BioMed Central
%R 10.1186/1742-4690-10-12
%X Background HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. Findings To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. Conclusions M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
%K HIV
%K Entry
%K CD4 binding site
%K gp120
%K Shedding
%K Inhibition
%U http://www.retrovirology.com/content/10/1/12