%0 Journal Article
%T Incorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells
%A Dongju Jung
%A Itsunari Minami
%A Patel Sahishnu
%A Jonghwan Lee
%A Bin Jiang
%A Qinghua Yuan
%A Liu Li
%A Sachiko Kobayashi
%A Yong Chen
%A KiBum Lee
%A Norio Nakatsuji
%J Journal of Nanobiotechnology
%D 2012
%I BioMed Central
%R 10.1186/1477-3155-10-23
%X Small molecules, peptides, and functionalized gold nanoparticles were successfully incorporated with polymethylglutarimide (PMGI) nanofibers through electrospinning. The PMGI nanofibers functionalized by the grafted AuNPs, which were labeled with cell-adhesive peptides, enhanced HeLa cell attachment and potentiated cardiomyocyte differentiation of human pluripotent stem cells.PMGI nanofibers can be functionalized simply by co-electrospinning with the grafting materials. In addition, grafting functionalized AuNPs enable high-density localization of the cell-adhesive peptides on the nanofiber. The results of the present study suggest that more cell type-specific synthetic substrata can be fabricated with molecule-doped nanofibers, in which diverse functional molecules are grafted alone or in combination with other molecules at different concentrations.
%K Molecule-doped nanofiber
%K Synthetic nanofiber substrata
%K Functionalized gold nanoparticles
%U http://www.jnanobiotechnology.com/content/10/1/23/abstract