%0 Journal Article
%T Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application
%A Clare Hoskins
%A Yue Min
%A Mariana Gueorguieva
%A Craig MacDougall
%A Alexander Volovick
%A Paul Prentice
%A Zhigang Wang
%A Andreas Melzer
%A Alfred Cuschieri
%A Lijun Wang
%J Journal of Nanobiotechnology
%D 2012
%I BioMed Central
%R 10.1186/1477-3155-10-27
%X Here we synthesize IONPs of core diameter 30£¿nm and gold coat using the seeding method with a poly(ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibility and increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV¨Cvis absorption, TEM, and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultant hybrid nanoparticles (HNPs) possessed a maximal absorbance at 600£¿nm. After laser irradiation in agar phantom a ¦¤T of 32¡ãC was achieved after only 90£¿s exposure (50 ¦ÌgmL-1). The HNPs appeared to decrease T2 values in line with previously clinically used MRI contrast agent Feridex£¿.The data highlights the potential of these HNPs as dual function MRI contrast agents and nano-heaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery.
%K Magnetic nanoparticles
%K Gold nano-shells
%K Magnetic resonance imaging
%K Surface plasmon resonance
%K Multifunctional nanoparticles
%U http://www.jnanobiotechnology.com/content/10/1/27/abstract