%0 Journal Article
%T The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-¦Ã
%A Sadayuki Hashioka
%A Andis Klegeris
%A Patrick L McGeer
%J Journal of Neuroinflammation
%D 2012
%I BioMed Central
%R 10.1186/1742-2094-9-113
%X We examined the effects of SAHA on interferon (IFN)-¦Ã-induced neurotoxicity of human astrocytes and on IFN-¦Ã-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 in human astrocytes. We also studied the effects of SAHA on the astrocytic production of two representative IFN-¦Ã-inducible inflammatory molecules, namely IFN-¦Ã-inducible T cell ¦Á chemoattractant (I-TAC) and intercellular adhesion molecule-1 (ICAM-1).SAHA significantly attenuated the toxicity of astrocytes activated by IFN-¦Ã towards SH-SY5Y human neuronal cells. In the IFN-¦Ã-activated astrocytes, SAHA reduced the STAT3 phosphorylation. SAHA also inhibited the IFN-¦Ã-induced astrocytic production of I-TAC, but not ICAM-1. These results indicate that SAHA suppresses IFN-¦Ã-induced neurotoxicity of human astrocytes through inhibition of the STAT3 signaling pathway.Due to its anti-neurotoxic and anti-inflammatory properties, SAHA appears to have the therapeutic or preventive potential for a wide range of neuroinflammatory disorders associated with activated astrocytes.
%K HDAC inhibitor
%K SAHA
%K STAT3
%K I-TAC
%K Astrocytes
%K Neuroinflammation
%K Neurodegenerative diseases
%U http://www.jneuroinflammation.com/content/9/1/113/abstract