%0 Journal Article
%T The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine
%A Christopher J Womack
%A Michael J Saunders
%A Marta K Bechtel
%A David J Bolton
%A Michael Martin
%A Nicholas D Luden
%A Wade Dunham
%A Melyssa Hancock
%J Journal of the International Society of Sports Nutrition
%D 2012
%I BioMed Central
%R 10.1186/1550-2783-9-7
%X Thirty-five trained male cyclists (age = 25.0 ¡À 7.3 yrs, height = 178.2 ¡À 8.8 cm, weight = 74.3 ¡À 8.8 kg, VO2max = 59.35 ¡À 9.72 ml¡¤kg-1¡¤min-1) participated in two computer-simulated 40-kilometer time trials on a cycle ergometer. Each test was performed one hour following ingestion of 6 mg¡¤kg-1 of anhydrous caffeine or a placebo administered in double-blind fashion. DNA was obtained from whole blood samples and genotyped using restriction fragment length polymorphism-polymerase chain reaction. Participants were classified as AA homozygotes (N = 16) or C allele carriers (N = 19). The effects of treatment (caffeine, placebo) and the treatment ¡Á genotype interaction were assessed using Repeated Measures Analysis of Variance.Caffeine supplementation reduced 40 kilometer time by a greater (p < 0.05) magnitude in AA homozygotes (4.9%; caffeine = 72.4 ¡À 4.2 min, placebo = 76.1 ¡À 5.8 min) as compared to C allele carriers (1.8%; caffeine = 70.9 ¡À 4.3 min, placebo = 72.2 ¡À 4.2 min).Results suggest that individuals homozygous for the A allele of this polymorphism may have a larger ergogenic effect following caffeine ingestion.Prior studies have established the ergogenic benefits of caffeine for both high-intensity short-duration performances [1-3], as well as endurance performance [4-6]. However, based on two studies that have reported individual data [3,6], approximately 30% of participants derive no ergogenic effects from caffeine ingestion. Doherty et al. [3] observed that four out of 14 subjects had no appreciable change in time to fatigue during running at a supramaximal workload following ingesting of caffeine. Meyers and Cafarelli [6] investigated the effects of acute caffeine supplementation on time to fatigue during repetitive quadriceps contractions. Three out of the 10 study participants did not respond to the caffeine or exhibited a worse performance under caffeine versus the placebo. Furthermore, not all studies report a significant ergogenic effect [7-9]. Beck et
%K Genetics
%K Cycling
%K Caffeine
%K Endurance performance
%U http://www.jissn.com/content/9/1/7