%0 Journal Article
%T Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1
%A Sylwia Sluczanowska-Glabowska
%A Maria Laszczynska
%A Katarzyna Piotrowska
%A Wojciech Glabowski
%A John J Kopchick
%A Andrzej Bartke
%A Magda Kucia
%A Mariusz Z Ratajczak
%J Journal of Ovarian Research
%D 2012
%I BioMed Central
%R 10.1186/1757-2215-5-18
%X To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on ovaries, we analyzed ovaries isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice, with low circulating plasma levels of IGF-1, and 6-month-old bovine growth hormone transgenic (bGHTg) mice, with high circulating plasma levels of IGF-1. The ages of the Laron dwarf mutants employed in our studies were selected based on their overall survival (up to ~ 4£¿years for Laron dwarf mice and ~ 1£¿year for bGHTg mice).Morphological analysis of the ovaries of mice that reached ~50% of their maximal life span revealed a lower biological age for the ovaries isolated from 2-year-old Laron dwarf mice than their normal-lifespan wild type littermates. By contrast, the ovarian morphology of increased in size 6£¿month old bGHTg mice was generally normal.Ovaries isolated from 2-year-old Laron dwarf mice exhibit a lower biological age compared with ovaries from normal WT littermates at the same age. At the same time, no morphological features of accelerated aging were found in 0.5-year-old bGHTg mice compared with ovaries from normal the same age-matched WT littermates.
%K Murine ovary
%K Laron dwarf mouse
%K Bovine growth hormone transgenic mouse
%K Growth hormone
%K Insulin-like growth factor-1
%K Aging
%U http://www.ovarianresearch.com/content/5/1/18/abstract