%0 Journal Article
%T High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes
%A Li Tian
%A Shiyin long
%A Chuanwei Li
%A Yinghui Liu
%A Yucheng Chen
%A Zhi Zeng
%A Mingde Fu
%J Lipids in Health and Disease
%D 2012
%I BioMed Central
%R 10.1186/1476-511x-11-54
%X Plasma HDL subclasses were quantified in CHD by 1-dimensional gel electrophoresis coupled with immunodetection.Although the particle size of HDL tend to small, the mean levels of low density lipoprotein cholesterol(LDL-C) and total cholesterol (TC) have achieved normal or desirable for CHD patients with or without diabetes who administered statins therapy. Fasting plasma glucose (FPG), triglyceride (TG), TC, LDL-C concentrations, and HDL3 (HDL3b and 3a) contents along with Gensini Score were significantly higher; but those of HDL-C, HDL2b+pre¦Â2, and HDL2a were significantly lower in CHD patients with diabetes versus CHD patients without diabetes; The pre¦Â1-HDL contents did not differ significantly between these groups. Multivariate regression analysis revealed that Gensini Score was significantly and independently predicted by HDL2a, and HDL2b+pre¦Â2.The abnormality of HDL subpopulations distribution and particle size may contribute to CHD risk in diabetes patients. The HDL subclasses distribution may help in severity of coronary artery and risk stratification, especially in CHD patients with therapeutic LDL, TG and HDL levels.
%K Coronary heart disease
%K High density lipoprotein subclasses
%K Diabetic mellitus
%K Fasting plasma glucose
%U http://www.lipidworld.com/content/11/1/54/abstract