%0 Journal Article
%T Efeito de diferentes doses de nandrolona associado ao treinamento de for a sobre o perfil fenot¨ªpico e ¨¢rea de sec  o transversa do m¨²sculo de ratos Effect of different doses of nandrolone associated with resistance training on muscle phenotypic profi le and cross-sectional area of rats
%A Rozangela Verlengia
%A Jonato Prestes
%A Ricardo Yukio Asano
%A Wagner Jos¨¦ da Silva
%J Revista Brasileira de Educa£¿£¿o F¨ªsica e Esporte
%D 2013
%I Escola de Educa??o F¨ªsica e Esporte da Universidade de S?o Paulo (EEFEUSP)
%X O presente estudo avaliou a influ¨ºncia de diferentes doses de decanoato de nandrolona (DN) associado ao Treinamento de For a (TF) sobre o fen¨®tipo de fibras e ¨¢rea de sec  o transversa (AST) do m¨²sculo extensor longo dos dedos (EDL) em ratos "Wistar". Os animais foram divididos em sete grupos: controle (GC) e grupos de acordo com a concentra  o de DN (0,1, 1, 2, 5, 10 e 20 mg/kg) administrada intramuscular 3 vezes/semana. O TF consistiu de saltos em meio l¨ªquido (carga 50-70% do peso corporal) 3x/semana, durante cinco semanas. A associa  o do TF e DN promoveu a  o modulat¨®ria sobre os tipos de fibras. Houve hipertrofia das fibras de contra  o r¨¢pida (tipo II) em compara  o com as fibras de contra  o lenta (tipo I). Em conclus o, apesar da associa  o do TF com DN aumentar a AST muscular e alterar o fen¨®tipo das fibras, n o houve efeito gradual das doses mais altas. The aim of the present study was to evaluate the influence of different doses of nandrolone decanoate (ND) associated with Strength Training (ST) on the phenotype of fibers and cross-sectional area (CSA) of the extensor digitorum longus (EDL) in Wistar rats. The animals were divided into seven groups: control (CG) and the groups according to the dose of ND administered (0,1, 1, 2, 5, 10 e 20 mg/kg). The ST consisted of water jumping with loads of 50-70% of their body mass, three times per week during five weeks. The association of ST with ND promoted a modulatory role on the muscle fiber types. There was a hypertrophy of fast twitch fibers (type II) as compared with slow twitch (type I). In conclusion, although the association of ST with ND increased muscle CSA and modified fiber phenotype, there was no additional effect of higher doses.
%K Treinamento de for a
%K Ester¨®ide anabolizante
%K Fibras musculares
%K ¨¢rea de sec  o transversa muscular
%K Strength training
%K Anabolic steroid
%K Muscle fibers
%K Muscle cross-sectional area
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-55092013000100009