%0 Journal Article
%T Radio-protective role of antioxidant agents
%A Alireza Shirazi
%A Ehsan Mihandoost
%A Seied Rabie Mahdavi
%A Mehran Mohseni
%J Oncology Reviews
%D 2012
%I PAGEPress Publications
%R 10.4081/oncol.2012.e16
%X Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects. Therefore, we propose that in the future, antioxidant radio-protective agents may improve the therapeutic index in radiation oncology treatments.
%K radio-protectors
%K antioxidants
%K herbal radio-protectors
%K vitamin E
%K melatonin.
%U http://www.oncologyreviews.org/index.php/or/article/view/200