%0 Journal Article
%T Effect of rosemary (Rosmarinus officinalis) extract on the biodistribution of 99mTc sulphur colloid and on the radiolabeled blood constituents
%A Eser U£¿ar
%A Serap Teks£¿z
%A £¿i£¿dem £¿£¿hedef
%A Ayfer Yurt K£¿l£¿ar
%J Revista Brasileira de Farmacognosia
%D 2013
%I Sociedade Brasileira de Farmacognosia
%X With this study we evaluated the effects of the herb rosemary (Rosmarinus officinalis L. Lamiaceae) extract on the labeling of blood constituents with technetium-99m (99mTc) labeled sulphur colloid and on the biodistribution of 99mTc-Sulphur Colloid in Wistar albino rats. For this purpose, two groups of animals (male wistar rats, 130-140 g) were treated (1 mL) with a rosemary extract (750 mg/kg body wt.,n=9) and water (control, n=9) separately by gavage for five days. 99mTc-Sulphur Colloid was administrated by intravenous injection; organs/tissues were withdrawn and weighted. Blood was centrifuged, plasma and blood cells were isolated. The radioactivity was counted to calculate the percentage of activity per gram for each organ/tissue and percentage of activity in blood cells and plasma. A significant increase (p<0.05) in the uptake of 99mTc-Sulphur Colloid in the liver after the treatment with rosemary extract was observed. These results indicate that the substances or metabolites of the rosemary extract would change the biodistribution of99mTc-Sulphur Colloid.
%K biodistribution
%K blood
%K rats
%K Rosmarinus officinalis
%K technetium-99m
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000100025