%0 Journal Article
%T Cholinesterase inhibitors for Parkinson¡¯s disease-related visual hallucinations unresponsive to atypical antipsychotics
%A Tomasz Sobow
%J Archives of Medical Science
%D 2007
%I Termedia Publishing House
%X Introduction: Considering lack of accepted guideline in cases of Parkinson¡¯s disease-related visual hallucinations with poor response or intolerance to antipsychotics, and their possible cholinergic pathogenesis, the trial with cholinesterase inhibitors seems to be legitimated. Material and methods: Five patients with PD (with or without dementia) complicated by VH and unresponsive to atypical antipsychotics were offered a 12-week, open-label trial of a cholinesterase inhibitor. Results: All 5 subjects completed the trial with no major adverse effects and, noteworthy, no discontinuations due to adverse events. VH resolved in 4 subjects and were markedly diminished in one person. Neither changes in UPDRS scores nor exaggeration of subjective complaints about extrapyramidal symptoms were noted during treatment. Conclusions: Cholinesterase inhibitors, rivastigmine or donepezil, might represent a useful alternative to antipsychotics for patients with PD accompanied by VH even in the absence of dementia.
%K cholinesterase inhibitors
%K rivastigmine
%K donepezil
%K Parkinson¡¯s disease
%K hallucinations
%K clinical trial
%K open label
%U http://www.termedia.pl/magazine.php?magazine_id=19&article_id=7868&magazine_subpage=FULL_TEXT